Fatal Colloid Cysts: A Systematic Review.
World Neurosurg. 2017 Aug 08;:
Authors: Lagman C, Rai K, Chung LK, Nagasawa DT, Beckett JS, Tucker AM, Yang I
OBJECTIVE: To accurately characterize patient characteristics and the clinical presentation of fatal colloid cysts.
METHODS: A systematic literature search of three popular databases was performed. Inclusion criteria were individuals with sudden-onset death and colloid cysts identified on imaging and/or autopsy. The cause of death must have been ascribed to the colloid cyst. Deaths precipitated by lumbar puncture were excluded. Clinical data were extracted and descriptive statistics were ascertained. Subgroup analyses were performed to compare adults to pediatric patients.
RESULTS: A total of 107 patients were included. The mean age was 28.13 years (SD 13.26, range 6-79 years). Males and females were equally affected. Headache was the most frequent symptom (n = 86, 80.37%). There were 6 patients (5 adults and 1 child) that reported positional headaches. The mean duration of signs and symptoms was shorter in adults versus pediatric patients (2.10 days vs 6.50 days, p = 0.02) and more adults presented with signs and symptoms for less than 24 hours than did pediatric patients (37.50% vs 5.56%, p = 0.01). Colloid cyst mean diameter was 2.00 cm (SD 1.07, range 0.50-7.90 cm) and 95.71% measured 1 cm or larger.
CONCLUSION: Our data suggests that the prodrome preceding sudden death appears shorter in adults with more adults presenting with symptoms for less than a day, and most colloid cysts measured one centimeter or larger.
PMID: 28801184 [PubMed – as supplied by publisher]
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