Publication date: Available online 12 August 2017
Source:Journal of Neuroscience Methods
Author(s): Qingbao Yu, Yuhui Du, Jiayu Chen, Hao He, Jing Sui, Godfrey Pearlson, Vince D. Calhoun
BACKGROUNDA key challenge in building a brain graph using fMRI data is how to define the nodes. Spatial brain components estimated by independent components analysis (ICA) and regions of interest (ROIs) determined by brain atlas are two popular methods to define nodes in brain graphs. It is difficult to evaluate which method is better in real fMRI data.NEW METHODHere we perform a simulation study and evaluate the accuracies of a few graph metrics in graphs with nodes of ICA components, ROIs, or modified ROIs in four simulation scenarios.RESULTSGraph measures with ICA nodes are more accurate than graphs with ROI nodes in all cases. Graph measures with modified ROI nodes are modulated by artifacts. The correlations of graph metrics across subjects between graphs with ICA nodes and ground truth are higher than the correlations between graphs with ROI nodes and ground truth in scenarios with large overlapped spatial sources. Moreover, moving the location of ROIs would largely decrease the correlations in all scenarios.COMPARISON WITH EXISTING METHOD (S)Evaluating graphs with different nodes is promising in simulated data rather than real data because different scenarios can be simulated and measures of different graphs can be compared with a known ground truth.CONCLUSIONSince ROIs defined using brain atlas may not correspond well to real functional boundaries, overall findings of this work suggest that it is more appropriate to define nodes using data-driven ICA methods: than ROI approaches in real fMRI data.
from # & – All via ola Kala on Inoreader http://ift.tt/2wTYZ1v