Enhanced Pru p 3 IgE binding activity by selective free fatty acid-interaction

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Publication date: Available online 14 July 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Pawel Dubiela, Roberta Aina, Dominika Polak, Sabine Geiselhart, Piotr Humeniuk, Barbara Bohle, Stefano Alessandri, Rebecca Del Conte, Francesca Cantini, Tomasz Borowski, Merima Bublin, Karin Hoffmann-Sommergruber

Teaser

Upon binding to certain lipids, the major peach allergen, Pru p 3, undergoes conformational changes thus exposing one dominant IgE epitope. This conformational change enhances the allergenicity of Pru p 3.

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