We have read with great interest the review article by Villaseñor et al.  on metabolomics strategies for the identification of novel biomarkers associated with specific phenotypes of allergic asthma. The paper also suggests the usefulness of specific biological matrices in the metabolomics approach to respiratory pathologies, indicating preferentially bronchoalveolar lavage fluid (BALF), lung biopsy or sputum for exploratory studies on molecular mechanism of a respiratory disease, and plasma or urine for detecting diagnostic or prognostic biomarkers.
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