Inflammatory myofibroblastic tumors of the lung carrying a chimeric A2M–ALK gene: report of two infantile cases and review of the differential diagnosis of infantile pulmonary lesions

We report two infantile cases of pulmonary tumor carrying a chimeric A2M–ALK gene. A2M–ALK is a newly identified anaplastic lymphoma kinase (ALK)-related chimeric gene from a tumor diagnosed as fetal lung interstitial tumor (FLIT). FLIT is a recently recognized infantile pulmonary lesion defined as a mass-like lesion that morphologically resembles the fetal lung. Grossly, FLIT characteristically appears as a well-circumscribed spongy mass, whereas the tumors in these patients were solid and firm.

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